Hydrogen is a safe medical gas. In terms of disease prevention and treatment, several biological effects of medical gases have been experimentally proven. Carbon monoxide, hydrogen sulfide, and nitric oxide play important physiological roles as low-level signaling molecules. However, these gases are also highly toxic molecules at high concentrations. The outstanding advantage over hydrogen is that it is not cytotoxic.
For mammals, hydrogen has long been considered a non-functional inert gas. Without a catalyst, hydrogen does not react with any biological compounds (including oxygen molecules) at body temperature. In some bacteria, hydrogen can be metabolized by hydrogenase. No functional hydrogenase genes have been found in mammals. Although, for example, there are hydrogenase descendant proteins in the mitochondria of animal cells, these molecules have not been found to catalyze the decomposition of hydrogen. This is why hydrogen gas has always been considered non-functional in our cells.
However, this concept description was completely overturned in 2007, because the results of the study proved that hydrogen can prevent and treat oxidative damage. This effect is through the selective neutralization of hydroxyl radicals and peroxynitroso. Hydrogen showed a cytoprotective effect in cultured cells and a significant therapeutic effect in the oxidative stress model.
Subsequent studies have revealed that hydrogen has a wide range of disease prevention and treatment effects. These published research papers have found that hydrogen has a significant therapeutic effect on oxidative stress damage in most organs. In addition, the study also showed that hydrogen showed multiple functions in most tissue model animals, such as anti-inflammatory, anti-allergic, anti-apoptotic effects and regulation of autophagy. Hydrogen even has the effect of promoting energy metabolism.
Because hydrogen has almost no toxicity, hydrogen has great application potential. In cell and animal experiments, it does not show any cytotoxicity even at high concentrations. The biological safety of hydrogen has long had a lot of evidence in the field of diving medicine, which provides an important basis for the practical application of hydrogen. Some diving medical studies have found that the human body is very safe for several days of exposure under dozens of atmospheric pressure. Inhalation of 1-4% hydrogen shows a good disease treatment effect, and the clinical application of hydrogen provides greater potential. Under such concentration conditions, there is no concentration condition for hydrogen combustion, which can fully meet the needs of hydrogen application.
The method of using hydrogen to treat diseases.
Inhaling hydrogen is a simple and direct treatment method, which can be through a ventilator, mask or nasal catheter. Hydrogen inhalation can quickly dissolve in the blood and spread to the whole body through the blood circulation, so hydrogen inhalation is the most suitable method to combat acute oxidative stress.
Comment: Here, hydrogen inhalation is used to treat acute diseases. In fact, it is not so accurate. Hydrogen inhalation is still a reasonable method not only for acute diseases, but also for acute attacks of chronic diseases.
At room temperature under normal pressure, the solubility of hydrogen in water is 0.8 mM (1.6 mg / L or 1.6 ppm). But hydrogen does not affect the pH of water. Drinking hydrogen water is very convenient. Portable hydrogen water equipment such as hydrogen water cups can be used to provide conditions for the daily application of hydrogen water. Hydrogen saline can also be injected intravenously or intraperitoneally. This method has its advantages over direct drinking, but it is a medical method and must be approved for clinical application. Hydrogen dissolved in physiological saline is also suitable for hydrogen eye drops. Of course, washing your eyes with clean hydrogen is also a better way.
During cold storage in vitro of organs such as the heart, hydrogen can be transferred to the heart graft by injecting in a water bath, effectively reducing myocardial damage caused by cold ischemia-reperfusion. Some scholars have established devices for soaking organs in saturated hydrogen solution during refrigeration.
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